Abstract

Research Article

Can we predict Alzheimer’s Disease through the eye lens?

Sandeep CS*, Vijayakumar N and Sukesh Kumar A

Published: 22 May, 2020 | Volume 4 - Issue 1 | Pages: 038-040

Alzheimer’s Disease (AD) is a common dementia problem of the old population. The two main hallmarks of AD are tau protein and amyloid-beta protein. The relevant investigations on AD suggest that these proteins are also seen in the eye. There are many tests and imaging modalities are used for AD diagnosis. But these techniques are still unable to predict the disease effectively. In this regard, the lens of the eye may help in diagnosing AD. Therefore, a reliable technique for measuring the lens or retina must be selected. In this paper, we focus on the different types of retinal diseases occur in AD patients and the use of the Optical Coherence Tomography (OCT) technique is used for diagnosing AD. 

Read Full Article HTML DOI: 10.29328/journal.ijceo.1001031 Cite this Article Read Full Article PDF

Keywords:

Alzheimer’s Disease; Early diagnosis; Retina; OCT

References

  1. Sandeep CS, Sukesh Kumar A. A Review on the Early Diagnosis of Alzheimer’s Disease (AD) through Different Tests, Techniques and Databases. AMSE J. 2015; 76: 1-22.
  2. Ohno-Matsu K. Parallel findings in age-related macular degeneration and Alzheimer’s disease. Prog Retin Eye Res. 2011; 30: 217–238. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21440663
  3. Mapstone M, Dickerson K, Duffy CJ. Distinct mechanisms of impairment in cognitive ageing and Alzheimer’s disease. Brain. 2008; 131: 1618-1629. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/18385184
  4. Krasodomska K, Lubinski W, Potemkowski A, Honczarenko K, Pattern electroretinogram (PERG) and pattern visual evoked potential (PVEP) in the early stages of Alzheimer’s disease. Doc Ophthalmol. 2010; 121: 111-121. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20549299
  5. Guo L, Duggan J, Corderio MF. Alzheimer’s disease and retinal neurodegeneration. Curr Alzheimer Res. 2010; 7: 3-14. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20205667
  6. Mei M, Leat S. Suprathreshold contrast matching in maculopathy. Invest Ophthalmol Vis Sci. 2007; 48: 3419-3424. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17591917
  7. Kesler A, Vakhapova V, Korczyn AD, Naftalive E, Neudorfer M. Retinal thickness in patients with mild cognitive impairment and Alzheimer’s disease. Clin Neurol Neurosurg. 2011; 113: 523-526. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21454010
  8. Oliveira LT, Louzada PR, Mello FG, Ferreira ST. Amyloid-b decreases nitric oxide production in cultured retinal neurons:a possible mechanism for synaptic dysfunction in Alzheimer’s disease? Neurochem Res. 2011; 36: 163-169. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20936504
  9. Berisha F, Feke GT, Trempe CL, McMeel JW, Schepens CL. Retinal Abnormalities in early Alzheimer’s disease. Invest Ophthalmol Vis Sci. 2007; 48: 2285-2289. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17460292
  10. Sandeep CS, Sukesh Kumar A. The Early Diagnosis of Alzheimer’s Disease Using Advanced Biomedical Engineering Technology”, Neurological Disorders and Imaging Physics. 2: Application to Autism Spectrum Disorders and Alzheimer's, IOP Expanding Physics, 2019.
  11. Sandeep CS, Sukesh Kumar A, Mahadevan H, Manoj P. Analysis of Retinal OCT Images for the Early Diagnosis of Alzheimer's. Disease”, Springer-Advances in Intelligent Systems and Computing book series (AISC). 2018; 749: 509-520.

Figures:

Figure 1

Figure 1

Figure 1

Figure 2

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?