Abstract

Case Report

Chlorambucil induced papilledema: a serious yet reversible side effect of chemotherapy

Sulena and Himanshu Kaushal*

Published: 25 April, 2022 | Volume 6 - Issue 1 | Pages: 013-014

Papilledema is optic disc swelling due to high intracranial pressure. Possible conditions causing high intracranial pressure and papilledema include intracerebral mass lesions, cerebral hemorrhage, head trauma, meningitis, hydroce-phalus, spinal cord lesions, impairment of cerebral sinus drainage, anomalies of the cranium, and idiopathic intracranial hypertension (IIH) [1].

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References

  1. Rigi M, Almarzouqi SJ, Morgan ML, Lee AG. Papilledema: epidemiology, etiology, and clinical management. Eye Brain. 2015; 7: 47-57. PubMed: https://pubmed.ncbi.nlm.nih.gov/28539794/
  2. National Center for Biotechnology Information. "PubChem Compound Summary for CID 2708, Chlorambucil" PubChem. 2021. https://pubchem.ncbi.nlm.nih.gov/compound/Chlorambucil
  3. Bregeat M, Hernians R. Oedenia papillaire spontanerrient criable aucous d'um traitement par le chlorambucil. Bull SOC Beige Oplztlialmol. 1972; 1960567-69.
  4. Al-Tweigeri T, Nabholtz JM, Mackey JR. Ocular toxicity and cancer chemotherapy: A review. Cancer. 1996; 78: 1359-1373. PubMed: https://pubmed.ncbi.nlm.nih.gov/8839540/
  5. Gonsalves WI, Zent CS, Pulido JS, Patnaik MM. Visual loss in early-stage chronic lymphocytic leukemia. J Clin Oncol. 2013; 31: e280-e282. PubMed: https://pubmed.ncbi.nlm.nih.gov/23650405/ 

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